Hatena::Groupnuke

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一覧 近コメ 近トラ SI 広島長崎原爆の威力、それぞれ67, 88TJ(TNT 16, 21kt) asking QLOOKアクセス解析
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2015-04-03

BurlakovaとBusbyのBiphasic仮説の傍証か?  診療・治療側は低線量の影響評価 治療治験発掘にご執心なのかな? エックス線を医療・診断に用いると、低線量被曝に対して "強化される" なのかな?これが当方 英語力のほぼ限界か、、

07:54

ECRRは 内部被曝の重視と あと 低線量域におけるBiphasicかんとか。 - 核 - nuke

○○重要論文!?→YH: 低線量:50μGy後のほうが100μGy後よりもDNA修復の効率 悪い のかも。→内田_kawasaki: - 核 - nuke

J R Soc Interface. 2014 Nov 6; 11(100): 20140783.

doi: 10.1098/rsif.2014.0783

PMCID: PMC4191111

Increased apoptosis and DNA double-strand breaks in the embryonic mouse brain in response to very low-dose X-rays but not 50 Hz magnetic fields

Shreya Saha,1,† Lisa Woodbine,1,† Jackie Haines,2 Margaret Coster,2 Nicole Ricket,1 Lara Barazzuol,1 Elizabeth Ainsbury,2 Zenon Sienkiewicz,2 and Penny Jeggo1

Abstract

The use of X-rays for medical diagnosis is enhancing exposure to low radiation doses. Exposure to extremely low-frequency electromagnetic or magnetic fields is also increasing. Epidemiological studies show consistent associations of childhood leukaemia with exposure to magnetic fields but any causal relationship is unclear. A limitation in assessing the consequence of such exposure is the availability of sensitive assays. The embryonic neuronal stem and progenitor cell compartments are radiosensitive tissues. Using sensitive assays, we report a statistically significant increase in DNA double-strand break (DSB) formation and apoptosis in the embryonic neuronal stem cell compartment following in utero exposure to 10–200 mGy X-rays. Both endpoints show a linear response. We also show that DSB repair is delayed following exposure to doses below 50 mGy compared with 100 mGy. Thus, we demonstrate in vivo consequences of low-dose radiation. In contrast to these impacts, we did not observe any significant induction of DSBs or apoptosis following exposure to 50 Hz magnetic fields (100 or 300 µT). We conclude that any DSB induction by treatment with magnetic fields is lower than following exposure to 10 mGy X-rays. For comparison, certain procedures involving computed tomography scanning are equivalent to 1–5 mGy X-rays.

Keywords: low-dose radiation, extremely low-frequency electromagnetic fields, apoptosis, DNA double-strand breaks, DNA damage response

Increased apoptosis and DNA double-strand breaks in the embryonic mouse brain in response to very low-dose X-rays but not 50 Hz magnetic fields

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